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  <title>The Evaluation of Antibacterial Activity in Nanoparticles Ointment Preparation using Ethanol Extract of Miana Leaves (Coleus Atropurpureus (L.) Benth)</title>
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  <namePart>Tria Prayoga</namePart>
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   <dateIssued>2023</dateIssued>
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 <note>ABSTRACT&#13;
&#13;
Objective(s):  Compared the nanoparticles form of Miana leaves with  its  extracts, even in single state or ointment preparation.  Hence, SPSS program  using Paired T Test is obtained to know the differences between them.&#13;
Method: The method used in this research is experiment in which try to change the extract form to be nanoparticles and be compared. The mixture of Poly Acrylic Acid (PAA) and calcium chloride using ionic glass method could change the size of Miana leaves' ethanol extract to be nanoparticle with the average diameter amounted 89,77 nm.  The  equality  showed  that  2,50%  of  Miana  leaves  is  equal  with  1, 17%  of nanoparticles Miana leaves extract.&#13;
Results: The  result indicated  that  ethanol  Miana leaves extract  had  antibacterial activities    toward    Staphylococcus    aureus,     Escherichia    coli,     Pseudomonas aeruginosa. The nanoparticles form proven can improve the stability and medicine's administration.  In the medicine administration system,  nanoparticles has function as carrier  by dissolving,  trap,  encapsulate,  and  attached the  medicine in  the  matrix. Then, by mixed poly acrylic acid and calcium chloride using ionic glass method, the nanoparticles would be formed.&#13;
Conclusion:  This  research  indicated  that  Miana  leaves  extract  of  nanoparticles ointment is safe and did not irritate the skin.&#13;
&#13;
&#13;
Keywords:   Miana,    antibacterial,    nanoparticles,    PAA,    ionic   glass,    ointment.</note>
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  <topic>Antibacterial</topic>
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 <subject authority="">
  <topic>nanoparticles</topic>
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 <subject authority="">
  <topic>Miana</topic>
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 <subject authority="">
  <topic>ionic glass</topic>
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  <topic>ointment.</topic>
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